Wang Lab abstract markThe Wang Lab @ EIT王权权课题组Eastern Institute of Technology, Ningbo · 宁波东方理工大学
EIT · NINGBO Explore EIT

Chemistry × Biology

Chemistry,
reprogrammed
by enzymes.

We develop new-to-nature enzymatic reactions and precision strategies for carbohydrate synthesis—bridging radical chemistry, directed evolution and sustainable biomanufacturing.

以酶催化拓展合成边界，以精准化学创造糖类分子。

Explore our research Join the lab

01 — Mission

Expanding what enzymes can make—and how molecules can be made.

拓展酶催化功能，重塑分子合成方式。

Our laboratory works at the boundary of synthetic chemistry and biocatalysis. We combine mechanistic design, enzyme engineering and light-driven radical chemistry to address selectivity challenges that are difficult for conventional catalysts alone.

02 — Research

Three connected frontiers

Full research program
01

New-to-Nature Biocatalysis

酶促非天然反应

We reprogram enzyme scaffolds for new-to-nature reactivity by coupling light- and electricity-enabled radical generation with active-site control, enabling bond formation with high chemo- and stereoselectivity.

PhotobiocatalysisEnzyme-controlled radicalsDirected evolution
02

Precision Glycoscience

糖类物质精准合成

We develop catalytic routes to architecturally diverse C- and N-glycosides, with particular emphasis on programmable glycosyl-radical precursors, modular coupling partners and anomerically defined products.

C- & N-glycosidesGlycosyl radicalsAnomeric control
03

Sustainable Synthesis

可持续合成与生物制造

We translate enabling reactions into integrated enzymatic cascades, linking engineered catalysts with biosynthetic modules to deliver complex, high-value carbohydrate molecules through concise and resource-efficient routes.

Enzyme cascadesSynthetic biologyBiomanufacturing

04 — Selected work

Ideas that changed the route

View publications
2025Photobiocatalysis

Directed Evolution of Class I Aldolases for Cooperative Photobiocatalytic Enantioselective Radical α-Alkylation of Aldehydes

Quanquan Wang†, Zhiyu Bo†, Michael S. Bratslavsky, Yang Yang*

J. Am. Chem. Soc. 147, 28601–28609
2024Glycoscience

N-glycoside synthesis through combined copper- and photoredox-catalysed N-glycosylation of N-nucleophiles

Qikai Sun†, Quanquan Wang†, Ming Joo Koh*, Gong Chen*

Nature Synthesis 3, 623–632
2022Photochemistry · Glycoscience

Visible light activation enables desulfonylative cross-coupling of glycosyl sulfones

Quanquan Wang, Boon Chong Lee, Ting Jun Tan, Wee Han Ser, Ming Joo Koh*

Nature Synthesis 1, 967–974
2022Glycoscience

Stereoselective synthesis of C-glycosides by harnessing glycosyl radicals from reductive iron catalysis

Quanquan Wang†, Qikai Sun†, Yi Jiang, Huixing Zhang, Gong Chen*, Ming Joo Koh*

Nature Synthesis 1, 235–244
2019C−H Activation · Glycoscience

Palladium-catalysed C−H glycosylation for synthesis of C-aryl glycosides

Quanquan Wang, Shuang An, Zhiqiang Deng, Wanjun Zhu, et al.

Nature Catalysis 2, 793–800

05 — Updates

From the lab

2025 · 12

The Wang Lab moves into EIT’s permanent campus and begins full operations.

课题组正式搬入永久校区，各项工作步入正轨。

2025 · 10

The Wang Lab officially begins its research program at EIT.

课题组正式开始工作。

2025 · 03

The Wang Lab launches at Eastern Institute of Technology, Ningbo.

王权权课题组在宁波东方理工大学正式成立。